This study concerns the analysis of soil-pipeline interaction through centrifuge modelling of cyclic lateral and axial of pipeline movement in submerged sand models. Soil response related to pipeline movement was quantified in terms of breakout, evolution of resistance forces during berm formation, combined vertical-lateral/axial trajectories of forces that define a possible yield envelope. A simplification of common offshore scenarios was adopted. Two series of geotechnical centrifuge tests were accomplished by applying controlled lateral and axial movements to assess load history possible to occur in the process of pipeline laying. The influence of vertical stress relaxation due to pipeline embedment was assessed relative to vertical forces in the instance of the movements. Typical assay results are related. The variation of the mobilized resistance was identified in terms of breakout forces and maximum forces in the berms relative to vertical force history due to pipeline embedment. The results revealed parabolic yield surface in combined vertical-lateral/axial loading conditions. The mobilized distances of the breakout axial resistance increased in relation to pipeline embedment percentage (w/D) diverging from values estimated in offshore practice that propose constant distances.