Refrigerant circuiting in condensers and evaporators has a significant effect in the performance of refrigeration systems. The optimized project of the refrigerant circuits in refrigeration systems with plate-fin heat exchangers is not trivial, due to the complexity of their representation as well as the high number of possible combinations, even when methodologies of intelligent optimization are used. The present work proposes a new methodology for the simultaneous optimization of refrigerant circuiting in air-air refrigeration systems with plate-fin heat exchangers. This new methodology, here defined as GAFIS (Genetic algorithms applied in filtered spaces), has proven to be more efficient than traditional methods. The GAFIS method was applied, in conjunction with a full refrigeration system simulator, Genesym, for the optimization of high performance commercial air-conditioning units. Typical cases were studied and a coefficient of performance improvement of up to 15.3 percent has been observed. In other studies, there were cases where the manufacturer s predicted cost was reduced in 3,85 percent (of total cost of the unit), while a similar thermal performance (capacity and COP) was maintained. Optimization tests, considering different diameters of tube, for the construction of heat exchangers, as well as systems with non-uniform air velocity distribution, were also performed with the GAFIS method. Microchannel condensers were also studied, given the current interest of industry on this kind of heat exchanger. The optimization of the refrigerant circuiting, in this case, would not be a major problem, due to the low computational cost of its simulation. However, simulation models appropriate for these types of heat exchangers have only been recently in use, and, to date, have not been adequately explored. In the present work, the influence on condenser performance of parameters that define the refrigerant circuiting has been investigated. For this purpose, a simulation model, based on local analysis, was developed. It was validated against experimental data, available from automotive microchannel condenser tests, with hydraulic diameters (refrigerantside) of 0.9 and 1.0mm for refrigerants R-134a, Fluid-H and R-1234yf. A direct relation was found between the geometric parameters that define the condenser refrigerant circuiting and its thermal performance. This fact can be appropriately used as guidance for expeditious design practices of the optimal refrigerant circuit of the condenser.