This piece of work aims to analyse the main spatial transformations, in and of the axis of urbanisation Rio de Janeiro (RJ, Brazil) – Juiz de Fora (MG, Brazil), which were configured as uneven geographical developments between 1861 and 1980. Our central question, in turn, is: What is the nature of these spatial transformations, what does generate them and what do they generate along the mentioned axis? In order to work in a way to critically bring space and time together; we will use the dialectical and historical materialist method and, mainly, the approach of uneven geographical developments of capitalism, a spatial expression of the theory of uneven and combined development. The axis Rio de Janeiro – Juiz de Fora was effectively set with the opening of União e Indústria Road, in 1861, between this city and Petrópolis (RJ, Brazil). The profits with coffee market allowed an indirect shift of capital that gave boost to the industrialisation of the three cities. This industrialisation happened together with the incipient urbanisation of the axis, characterised by the beginning of the domination of agrarian by urban life and the imposition of new logics and rationalities. In 1928, with the opening of Rio – Petrópolis Road, a new moment of the periodisation here adopted began, in which the cars supersede the trains and in which occurs significant industrial concentration in Rio de Janeiro and Duque de Caxias (RJ, Brazil) and a peripheral industrialisation of Juiz de Fora and Petrópolis, in addition to the expansion of the urban form in these four cities and to the consolidation of the ur-banisation of the axis.