The dynamic response of nonlinear structures has been a topic of interest in civil engineering research. Problems in which base-structure interaction is present have a great importance in structural analysis, since most structures rests on flexibel systems (soil or supports with dissipation). In this research area, the study of structures under the action of seismic loads represent a relevant topic, since this kind of excitations may excite several vibration modes and thus influence strongly the dynamic response. In this context, the prediction of the nonlinear structural behavior in frequency domain of structures under base excitation is a useful resource to assess the potential effects of sismic loads on these systems. In this thesis, a methodology for nonlinear dynamic analysis of plane frame structures under base excitation is presented considering geometric nonlinearity and elastic supports represented by elasto-plastic unidimensional springs. Trough a parametric analysis, the variability of the dynamic responses of slender structural systems under the actions of real earthquakes, synthetics earthquakes, as well as the action of multiple earthquakes is assessed. The structural systems here analyzed are discretized in space using a nonlinear finite element formulation. For the response in frequency domain, a scheme based on the Balance Harmonic Method and the Galerkin method, in conjunction with continuation methods, is formulated to obtain the nonlinear resonance curves. The nonlinear dynamic response in the time domain is calculated by direct integration of the equations of motion. For this, the Runge-Kutta method and the Newmark method in association with the iterative Newton-Raphson scheme are employed.