In the hydrocarbon extraction process, the sand control system is responsible for mitigating the production of solids in the producing zone of oil wells. Numerous problems are caused by excessive sand production that, as a consequence, may require production stoppages for well maintenance or even abandonment, causing high costs. The sand screen is one of the filtering structures that make up the sand control system and, therefore, its structural failure has been the subject of several studies. The objective of the present research is to use submodeling techniques to develop a workflow for sand screen integrity assessment. The proposed methodology consists of sequential analysis at different scales. At the field (global) scale the analysis considers the main components of the subsurface model in order to evaluate the stress and displacement field. Next, the displacements and stresses are input into the submodel at the sand screen scale using data transfer techniques. The submodeling approach was evaluated on two structural examples: the first consists of a plate under tension and the second a running shoe with elastoplastic soil behavior. Finally, the methodology is applied to a case study of structural integrity of sand screen from a vertical well subjected to compaction due to hydrocarbon extraction. The results show that submodeling is a viable alternative amid the challenges that reservoir and well modeling face due to the difference in scales of the surrounding rocks and the structural components in the production zone.