Large-scale multiple-antenna systems are a key technique for future wireless communications, which will serve tens of users per base station (BS). In this scenario, one problem faced is the large energy consumption as the number of receive antennas scales up. Recently, low-resolution analogto-digital converters (ADCs) have attracted much attention. Specifically, 1-bit ADCs in the front-end are suitable for such systems due to their low cost and low energy consumption. In this thesis, 1-bit ADCs are applied in three different system designs, which operate at the Nyquist rate and faster than Nyquist rates along with uniform and dynamic strategies. In the Nyquist-sampling system, low-resolution-aware channel estimation algorithms and a novel iterative detection and decoding scheme are proposed, where short block length low-density parity-check codes are considered for avoiding high latency. In the faster than Nyquist rates with uniform oversampling system, lowresolution-aware channel estimation and sliding window based detection algorithms are proposed due to their low computational cost and high detection accuracy. Particularly, analytical expressions associated with the Bayesian Cramér-Rao bounds for the oversampled systems are presented. Numerical results are provided to illustrate the performance of the proposed channel estimation algorithms and the derived theoretical bounds. In the dynamic-oversampling system, two different system designs are devised, namely, sum rate and mean square error based. Three different dimension reduction algorithms are presented and thoroughly investigated. Simulation results show that the systems with the proposed dynamic oversampling outperform the uniformly oversampled system in terms of the computational cost, achievable sum rate and symbol error rate performance.