This thesis aims to establish the determinant factors for the development of a new industry - the technology-based creative industries (TBCI) - in Brazil, focusing on the formation of innovation clusters. Building on the results of a literature review of the emergence and evolution of the creative industries and of the new opportunities generated by the digital convergence, the thesis presents a definition and the productive chain of the TBCI, a singular industry with an enormous growth potential. The growing importance of the regional locus in the innovation generation process and the impact of innovation on economic development highlight the fundamental role of establishing institutions such as collective learning, informal communication and knowledge creation, connection to leaders, the venture capital industry and the creative environment as central elements of innovation producing regional networks. The thesis identifies and assesses the determinants of success of innovation clusters based on a comparative analysis of ten clusters and science parks around the world and, then, makes an in-depth analysis of the Israel and Taiwan cases, two of the most successful clusters in the high technology industry, next to Silicon Valley. The research also examines the Brazil’s Science, Technology and Innovation Action Plan, from the perspective of policies and mechanisms therein to promote the development of the TBCIs in the country. Finally, this work introduces the location, structural and cultural advantages of a region, the city of Rio de Janeiro, which holds a great potential to develop a TBCI cluster in Brazil. From the assessment of the determinant factors in the most successful high technology innovation clusters; the analysis of nature and singularities of the TBCIs and the identification of the institutional gaps in the Brazilian policy, it is presented a set of recommendations that aim to transform the City of Rio de Janeiro in an international reference of the TBCI.