Interaction design has been finally recognized as a key factor for a broader acceptance and the effective utilization of applications and systems. Virtual environment (VE) applications are being developed in growing numbers and aiming to fulfill even more diverse and innovative needs. But the knowledge about interaction design and evaluation of VE applications is still recent and lacks well established methods and techniques. The focus of this study is the communicability and usability evaluation of the HybridDesk, an equipment designed for the interaction with VEs that includes three different interaction environments. The communicability evaluation method (CEM), based on the semiotic engineering, is an innovative and recent method, performing a qualitative evaluation focused in the reception by the user of the designer metacommunication message, at user interaction time, aiming to identify communicability issues and to produce the semiotic profiling of the metacommunication. There are several usability evaluation methods, both qualitative and quantitative, including some already applied to VEs. This study has applied some of these methods, favoring a qualitative evaluation, although also providing some quantitative results. It includes an heuristic evaluation as well as usage observation sessions with a focus on the user perception of the interaction, aiming to identify HCI issues in hybrid virtual environments. This study also produces a comparison of the evaluation results of the various methods applied, demonstrating that they all contribute in a distinct way to the evaluation results of the HybridDesk. The results also highlight and reinforce the importance of some interaction aspects, like the compatibility among the various signification systems involved during user interaction, and the need to look for the seamless integration of 1D, 2D and 3D tasks from the user perspective.