With the current requirements on emissions and fuel consumption in a context of very strict environmental laws, it is necessary to improve combustion engines performance to reduce greenhouse gas emissions. New technologies, such as Homogeneous Charge Compression Ignition or Spark-Assisted Compression Ignition (SACI), are alternatives to increase engine s efficiency. In this work, a MATLAB routine was created to predict the performance of SACI multimode combustion of methane and methane-hydrogen blends, using a two-zone thermodynamic model. A sensitivity analysis was realized to four performance parameters: thermal efficiency, NOx emissions, CO2 emissions and energy of the fuel, with several factors variations such as percentage of H2, engine speed, fuelair equivalence ratio, intake pressure and valve overlap, using experimental design tools to evaluate the impact of those factors over the performance parameters. The Box-Behnken Design indicated that engine speed, percentage of H2 and intake pressure are the most important SACI factors since they influence all engine performance parameters. On the other hand, fuel-air equivalence ratio was relevant in only one of them (NOx) and the valve overlap, as it was used in the experiments, showed no relevant impact on the results. Furthermore, a Univariate Analysis was done to compare Spark-Ignition and SACI engines efficiencies. The results showed that SACI engines performs better, with 7 percent - 17 percent higher efficiency and 90 percent - 96 percent IMEP s increase.