This research proposes to investigate the inter-religious spirituality of Nicholas of Cusa and his contributions to Christians today in the search for good coexistence between different religions or religious expressions in the world. In general, the research seeks to answer the following questions: who was Nicholas of Cusa, considering his historical, cultural, social and religious context? What is the importance of inter-religious dialogue today and how can Cusa s interreligious spirituality contribute to this debate? Therefore, the research starts from the period of the Late Middle Ages, especially the 15th century, the period in which Nicholas of Cusa lived, until the present day. Initially, a description of the life, work and ministry of Nicholas of Cusa is made in order to introduce him. Afterwards, an analysis of medieval spirituality is made, considering the changes and transformations that occurred at that time, which, somehow, contributed to a more open, innovative, questioning and inclusive spirituality. The purpose is to discuss movements that emerged both in the religious sphere and in the sphere of society at the time and that Cusan spirituality, in a certain way, was influenced by these transformations. Next, some works by Nicholas of Cusa are examined, such as, for example, De pace fidei and Cribratio Alchorani, whose intention is to demonstrate the interreligious spirituality of Cusa, based on his own works. And, finally, the importance of interreligious dialogue and his contributions to the same are discussed, for example, the proposals of theological and humanistic understanding. With regard to the methodological foundations, the research is based on a critical-reflexive analysis of the Cusan sources, the relevant bibliography and texts on the subject.