The COVID-19 pandemic has rapidly spread throughout the world. In Brazil, various organizations, such as the Brazilian Red Cross (CVB), have engaged in several actions against the spread of the virus and in support of the most vulnerable populations. In response to public health emergencies, immediate relief supplies are essential to reduce harm. To ensure the timely distribution of donations to beneficiaries, proper supply chain management (SCM) is fundamental. This dissertation aims to review CVB s processes in light of the literature, in order to promote real conditions for transformation in these processes, with a view to improving organizational performance and effectiveness in distributing relief items. Based on a Scoping Review of the literature, the state of the art on Critical Success Factors of Humanitarian Logistics in epidemiological crisis situations, such as COVID-19, and the best practices to achieve them were identified. In this work, a Case Study was conducted on CVB s logistics chain, in which, through interviews with experts and documentary analysis of official publications, the flowchart of current macro-processes (donation capture and receipt, donation distribution, branch receipt, last-mile distribution) was diagrammed. Next, in light of the literature, 10 opportunities for improvement were identified, resulting in the revision of its processes, reformulating and validating CVB s logistics macro-processes, where it was possible to conclude that the proposed improvements are feasible and present significant potential for positive impact on the organization s humanitarian activities.