The main objective of this research was to analyze the vulnerability, stress and social support in couples of families from communities affected by natural disasters in Mozambique, focusing on the Savane resettlement center. The theoretical basis was supported by Brofenbrenner s bio-ecological approach, which argues that the environment influences individuals and is influenced by them, also considering that the bio-ecological being is in a dialectical relationship with the psychological and the social, and no phenomenon can be understood in isolation. We also approached the line of psychopathologies of LaCapra (2004) and other authors, showing that, due to socioeconomic vulnerability, many of the couples experienced psychological violence that caused trauma and depression. The research is qualitative and quantitative, descriptive and exploratory. Forty couples with and without children from the Savane resettlement center participated in the study. A semi-structured script interview was conducted in which we sought to understand the level of (psychological) stress, coping strategies, resilience, and psychological consequences derived from the effects of natural disasters. The sociodemographic questionnaires were simultaneously applied to explore vulnerability (social and geographical) based on family income, place of residence, age, gender, profession, and level of education of the couples; and the social support questionnaire (SSQ) of Sarason, Levine, Basham, and Sarason (1983), Portuguese version by Matsukura, Marturano, and Oish (2002), to assess the level of satisfaction with social support (perceived and received). The content analysis of the interviews was performed from the frequency of words presented in the participants speech by the IraMuTeQ software (Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires) and in the quantitative analysis, the resources of the statistical software SPSS (Statiscal Package for Social Science) version 21 were used. The results indicated that these families experienced long-term reactions, conditioned to psychopathological problems that consequently influenced their way of life. It was highlighted that ongoing severe trauma can lead to significant impairment in emotion and behavior regulation and can directly impact how couples perceive themselves and their worldview. It was assumed that the lack of social support can influence vulnerability and the development of stress in couples. Overall, it is concluded that these families being disadvantaged had high rates of all disorders found after the IDAI, including post-traumatic stress disorder, generalized anxiety disorder, major depressive disorder, and panic disorder. Continued psychological intervention and follow-up is urgently proposed for this special group. However, the need for interventions to take into account culture and context is stressed, because what is diagnosed as pathological can vary widely across cultures.