Developing and building a prosthesis or orthosis with easy adaptation for the user is still a major challenge in the engineering area in general. In addition, the use of electromechanical elements inserts autonomy and portability as factors of difficulty in construction. Another point is that variations in human factors, such as spasticity, muscle tone or changes resulting from diseases such as cerebral palsy or nerve damage, interfere with the construction of the device. Therefore, the construction of an orthosis is a challenging and multidisciplinary job, which involves a deep and detailed analysis from the application to the actual construction. The use of Industry 4.0 techniques to make the orthosis comfortable, lightweight, and easy to use is fundamental to this, as is the analysis and processing of biosignals and control, making sure that each step is connected and adjusted so that it functions correctly. This aims to evaluate the theoretical and experimental methods of construction and dynamic evaluation of a bio-orthosis of upper limbs using the concept of industry 4.0, digital manufacturing processes, multi-structural optimization, bio-signal processes and non-linear control techniques. This study was motivated by the advancement of the use of digital manufacturing in the field of bio-medicine, by the great challenge from the point of view of control, by the variability that these processes can have in the construction of orthoses in improving the quality of life of people with disabilities.