The process of human occupation in Brazilian territory has caused profound changes in the environment for centuries. Since the first inhabitants, nature has undergone some change in its shape, to some degree of scale. If native traditional peoples have a concern to reconcile the man-environment relationship, the European invasion has reversed all this logic. From primitive processes to the use of modern mechanization, post-1500 Brazil showed human strength under nature and its consequent impacts. Despite the major or minor efforts, the denunciations proposed since the colonial period, the destruction of ecosystems of great local and global importance is advanced. Given this scenario, the country has biomes with enormous danger of irreversible losses if nothing is done. In this context, this thesis aims to understand these transformations in historical, geographical, and economic views, culminating in a quantitative analysis of land use from 2004 to 2019 focused on the municipalities of the two main threatened Brazilian biomes, Cerrado and Amazon. Through different instruments of spatial econometrics whose principles are the first laws of geography, it is intended to identify the factors that modified land use in the period mentioned and propose measures to mitigate the impact of the main vector of direct deforestation in the biomes mentioned: livestock. Through this analysis, it is intended to evaluate how the intensification of beef cattle culture alters emissions, the configuration of land use, can assist in complying with the Native Vegetation Protection Law and generates economic gains within an area with more than 1,700 municipalities. The goal is to determine the best policy of intensification of beef livestock activity considering the trade-off environment and economy. The choice will allow the country to be able to offer domestic and international consumers a more sustainable activity with minimization of the environmental impact generated and increased revenues. Considering all these facts, the thesis shows that changes in land use in four different classes – agriculture, livestock, forest, and other uses – are local phenomena whose sum has a relevant global impact. The results reinforce the importance of environmental and agricultural public policies and the observer in the differences between the municipalities in their formulation and implementation. For Brazil, there is an immense potential for both expanding the forest area with intensification and restoring large areas released with the increase of the beef production system. The country has in its hands a unique chance to have a sustainable livestock economically and environmentally with a government policy that considers local diversity.