Reading with a view to achieving comprehension is still a difficulty to be overcome by many students. Reading comprehension and, more specifically, inferences need to become an object of teaching, whose purpose is to form readers capable of producing meaning for what they read. Thus, if inferences demand a systematized teaching, our objective with this research was to analyze and describe 4th and 5th grade teachers knowledge about the teaching of inferences. In this study, 67 teachers who work or have worked in the 4th and/or 5th grade in schools of Rio de Janeiro participated. These teachers answered an electronic form containing the following instruments: 1) a questionnaire about the types of inferential and non-inference questions; 2) the Inferential Teaching Strategies Scale (EEEI); 3) a questionnaire about the teachers profile. The findings received a quantitative treatment, and the data analysis was structured in two stages: exploratory factor analysis and analysis of the frequency of responses. The results were discussed in the light of the cognitive theory of reading. In general, the results concerning inferential and non-inference questions, as well as reading comprehension strategies, indicated that teachers know both questions suitable for teaching inferences and comprehension strategies that have relevance in such teaching. In view of this teachers knowledge, a comprehension teaching perspective that understands reading as a meaning-making activity stood out. Regarding questioning, the teachers stated that they were familiar with process and product questions, not restricted to literal questions. The importance of the reader s prior knowledge to teach inferences seems to be part of the teachers knowledge. Through this research, it was possible to highlight and discuss the importance of the production of inferences for the formation of proficient and autonomous readers, as well as to have reading comprehension strategies and reflect on them as favorable ways to teach students to establish inferences authorized by the text. Finally, through what the teachers declared they knew about the teaching of inferences, we were able to analyze how issues related to reading comprehension and, more specifically, to inference are conceived by the teachers.