The region of the Middle São Francisco, in the interior of Bahia, in the stretch of river between the municipalities of Bom Jesus da Lapa and Serra do Ramalho is a region where different types of occupation have been allocated, being, therefore, a spatial cut with great potential to understand how the different relationships between society and nature can impact the differentiation of landscapes, especially the distribution of vegetation cover. The strong presence of the vazanteiras quilombola community, as well as the settlement of the population affected by the construction of the Sobradinho dam in the Serra do Ramalho Special Colonization Project in the 70s, made the middle São Francisco region an area of action for different ethno-environmental practices. Thus, this study aims to, from the use of geotechnologies, produce an analysis of the spatial cut from the perspective of changes in land use and land cover, in order to compare the evolutionary trajectory of the landscapes of quilombola and the settlement of the resettled population. The change detection analysis was developed using images from the Landsat collection, using geotechnology tools to produce data on the distribution of vegetation cover in different spatial contexts and monitoring of temporal series. The landscape metrics showed a strong differentiation in the behavior of the distribution of vegetation cover, varying moments of trend of losses and gains of vegetation area and in the presence of types of phytophysiomy, especially a great distinction between the intensity of processes in the territories of traditional and settlement of Serra do Ramalho, in relation to its surroundings.