The concept of the big Other, in Jacques Lacan, refers to the place of culture and language where the subject is formed. It arose from the Lacanian approach to the Freudian notion of the unconscious, when this author identifies the linguistic way of the unconscious to operate. Such a concept has an aspect of radical alterity, that is, a point of impossible complete meaning of existence, due to the insufficiency of words and symbols. Thus, the subject responds for particular modes of existence in front of his life, in order to deal with alterity. In this material, we question what different configurations the place of the Other can take in view of the responses that the subject seeks to build from what he receives from his culture. This question helps us to think about support for the treatment of this place to help subjective constructions. We start from the Lacanian development of the notion of the Other in three moments of his thought, related to the two subjective structures of neurosis and psychosis (paranoid and schizophrenic). Observing the plurality of social formations around different knowledge and practices between subjects, we understand that the concept of the Other, at the end of the Lacanian work, becomes Others - several symbolic places, different languages invented in social ties. In this way, we come to the understanding that the Other s alterity makes it instrumental. That is, its relationship with the subject is not given a priori, but constructed through the attribution of a subjective function. Contemplating the artifices of dealing with language and the conception of the Other helps to apprehend, in analytical listening, the emergence of elements that present themselves as unique resources in the clinic, arranged by the subject to formulate sustainable ways of existing.