The main objective of Responsibility in the philosophical system of Schopenhauer is trying to define the concept of responsibility by presenting some of the uses of this concept in selected texts by Schopenhauer. Since the his philosophy`s style and defining character is the relationship between metaphysics, theory of knowledge, aesthetics and ethic, we find it imprudent to analyze responsibility based solely on ethics and leaving aside the other three themes such as the formal conditions of the subject`s knowledge, the principle of sufficient reason, the law of motivation, the criticism of moral duty, aesthetics and ascetic contemplation, objectification degrees and Ideas. There is no doubt that the issue of suffering permeates all the works by Schopenhauer, and the same is true of this dissertation. Responsibility seems to us to be directly related to pain, affirming or denying the will to live.