Displacement of one fluid by another is a common process at petroleum industry, as completion and cementing operations of oil wells. The success of these fluids displacement guarantee the lifetime of the wells. The adequate operation occurs when the cement slurry distribution at the wall is homogeneous. In this work, experimental and numerical studies of Newtonian and non-Newtonian fluid displacement through annuli are performed. The experiments are performed using a scaled oil well model. The numerical solution of the governing conservation equations of mass and momentum is obtained using the finite volume technique and Fluent and OpenFOAM softwares. The multiphase modeling is performed using the volume of fluid (VOF) method. The effect of rheological parameters, density and viscosity ratios, geometry configuration, and flow rate on displacement efficiency was evaluated to optimize cementing operation. Tests were performed using model and real fluids, Newtonian and non-Newtonian. The displacement efficiency was evaluated analyzing the interface between fluids and measuring the density of the mixture at the annuli outlet through time.