The Acquired Immune Deficiency Syndrome (HIV/AIDS) is caused by HIV. In general, HIV is a retrovirus that attacks the immune system, primarily helper T lymphocytes (also called T4 or CD4 + T lymphocytes) which are normally found in the bloodstream and are responsible for all the coordination of the immune defense body. Several treatment strategies are being developed and tested, including the use of drugs that prevent the virus from entering the cell (entry inhibitor). These drugs represent a very interesting approach in the treatment of HIV/AIDS, since other types of drugs attack the virus only after the infection the lymphocytes. Among the promising candidates for new fusion inhibitors, the highlights are maraviroc, vicriviroc, aplaviroc and para-bicyclo AMD 3100. It was found that the bicyclic exhibit significant biological effects, and reduced toxicity to the central ring substituents attached to interfere in the activity these organic compounds. Thus, in this work, the AMD 3100 was considered a prototype for the synthesis of di-hydrazones, which represent a class of organic compounds defined by the presence of the functional group R1R2C = N-NR3R4. Studies have shown that several hydrazones and substituted hydrazones are associated with a broad biological applicability. The aromatic spacers used were the precursors centers 2,5-dimethoxyterephthalaldehyde, 2,5-dihydroxyterephthalaldehyde and terephthalaldehyde, which were modified in relative positions to a bioactive compounds such as furan acid hydrazide, thiophenic acid hydrazide and isonicotinic acid hydrazide by a condensation reaction. Thus, nine di-hydrazones were obtained and characterized by elemental analysis, by IR spectroscopic techniques, Raman and UV-Vis spectroscopy, thermogravimetric analysis and 1H NMR. A preliminary study in silico (computational) pharmacological evaluation was also conducted to evaluate the relative performance of some relevant molecular properties for the pharmacokinetics of a drug in the human body. The crystal structure was obtained for only one of the di-hydrazone. Based on the fact that metal ions in metallodrugs contribute to increasing the potential of the same and that the zinc complexes with AMD3100 are those with best biological results, there were attempts to obtain zinc complexes for each di-hydrazone synthesized. Three complexes were obtained dinuclear zinc(II), since the other ligands showed very low solubility to carry out the synthesis. The compounds were characterized by elemental analysis, FT-IR, Raman and UV-Vis spectroscopy and thermogravimetric analysis. It was concluded that the di-hydrazone reported in this work have very good yields important farmocinéticas and molecular properties that the obtained crystal structure shows two different conformations. In the complex , the coordination takes place by the arms pending N2O - donor system and the central aromatic ring substituents involved coordination (in the case of the oxygens of methoxyl groups and phenol).