The relationship between spirituality and the Bible is not just the relationship with a book, but with the Living Book. Christ, as seen in the testimony of mystics and biblical testimony, as well as in the theological reflection. The biblical experience, because it is conducted by the logic of the Incarnation, generates an integrative and humanizing spirituality. Unfortunately, many times the history of spirituality was marked by the absence of the biblical novelty, and, as a result, spirituality was associated exclusively with interior life or with what is immaterial. The experience of the Spirit in the Bible shows this type of association to be unfounded. On the contrary, life in the spirit integrates all human dimensions, generates life and concrete solidarity. The challenges of our time should lead us to be open to the newness of the Spirit, which must be seen and accepted, so that the dialog with the Sacred Scripture remains alive and liberating.