The power of prayer in the face of a major crisis is an important issue that has been discussed in the past months due to the planetary reach of the trouble caused by the Coronavirus outbreak. Generally, in the history of religions, it is well known that physical and spiritual health can never be untied. Similarly, it does not seem possible to work on the salvation of one s soul without considering one’s health. Therefore, this article aims to provide a basis for refl ecting on the power of prayer in times of crisis. Through theological bibliographical and exploratory research, we understand that the book of Job is exemplary regarding the refl ection on the relationship between faith and cure and the power of prayer. Nevertheless, the drama in Job s narrative does not provide a solution to the problem of the challenges of evil, neither suggests magical solutions to unburden the human suffering. Then, this article offers prayer models and experiences in times lived through the valley of the shadow of death (Psalm 23), accordingly to God’s heart, Christ s mind, and Saint John of the Cross mystical experience, and fi nally, how to pray in times of pandemic according to Pope Francis exhortations.