The objective of this work is to analyze the conduction of the malaise in the present days. The malaise in particularly, is a psychic distress. Inspired in the concept of governmentality, we will denominate the government of the malaise the ways to conduct the malaise. Therefore we will call upon the foucauldian notion of biopower, reference and backstage of the analysis, from which we will understand how modern s government of life was consisted. This is the basis that will be considered to reflect on today s government of life, where psychic malaise performs strategic roles. The government of the malaise will be analysed on the psychiatry context, precisely, certain pill discourse, discourse of biological psychiatry - focused in the regulation of almost all and any psychic malaise. We will also investigate the conduction of the malaise contained in some of the freudian productions, considering the elaboration of certain concepts, culminating with the concept of death drive.