Starting from the theme design and education, the main focus of this study is the school space, because it is the place, besides the family space, where children develop competences and cognitive abilities, collect their first sensations, impressions and begin the process of great physical, psychological and social changes. Based in authors such as Antônio Fontoura, Sonia Kramer, Maria Apparecida Mamede Neves and Rita Couto, the work takes on the challenge of approaching the object of investigation having theoretical fields structured around concepts such as Design in Education and Child Education. The investigation considered the conceptual references in which is based the theoretical framework of reflection about school spaces, mainly approaches by authors such as Antônio Viñao Frago, Agustín Escolano, Doris Kowaltowski, Mayumi Lima and Ana Lucia Goulart de Faria. The problem that guided the investigation was that: How Design and Education, when allied, may contribute with their respective bodies of knowledge, methodologies and practices for creating a living space, proper to the development, experiences and learning in the scope of the preschool? Guided by this problem, a project was carried out, in the Republic of Sao Tome and Principe, Africa, together with the work field, for the redetermination and renovation of three pilot schools - Creche School Primeiro de Maio; Kindergarten of Monte Café and Kindergarten Good Entrance. In face of the stages that made up the renovation project of the schools, the methodological approach of Design in Partnership was used aiming their validation by the users, by contributing with significant information allowing the discovery of proper solutions, generating a new value to configurations as well as school environments. The resignification of the spaces of the three schools was not made only by actions regarding the physical aspects of the school building, but it founded the valorization of human and pedagogic aspects, creating interactive environments, stimulating the playing, for the aesthetic experience. This resignification also enabled to establish immersive spaces of perception and contact with nature. The findings point to possibilities for developing school projects with a signed commitment with the quality of life of children and elaborating an example of the school space. By considering that schools are living spaces aimed to educational activities in strict sense, it is being said that school learning does not occur only when children are in classroom. The resignification of school spaces was a pilot experience being used as an inspiration so that other schools of Sao Tome and Principe may be contemplated and providing subsides to improve the quality of life of public schools in similar contexts, within Africa itself, and able to also be extended to schools of specific regions in Brazil.