The electric power reactor industry is based on rigid safety principles. The design criteria include seismic scenario. All safety related systems are designed to resist and to keep the operability during and after a postulated earthquake. It is suggested a procedure for the generation of in-structure seismic response spectra for secondary system design. A probabilistic approach is used and coupling effects between primary and secondary systems are taken into account. The proposed script uses SASSI system and can be used in general situations. A set of computer programs is developed to consider three-dimensional models and their responses for a generic base excitation, acting in 3 orthogonal directions; represent the coupling effect between primary and secondary systems, include the influence, on the response spectra, of the secondary system supports relative displacements; include approximated factors for transposition of elastic into inelastic response spectra; produce Uniformly Probable Response Spectra, including or not coupling effects; consider interfaces with other general programs, as the MS-EXCEL, for pos-processing purpose. The degree of automation, allows the production of response spectra including modeling refinements, reaching a more realistic analysis, without additional efforts beyond those already required by the conventional methodology. The proposed methodology is in the way of a site specific uniform hazard design response spectra, and of a consistent-risk seismic design.