Through centuries the human being seeks for optimum, it belongs to their nature. Always looked for improvements, to create favorable conditions, to optimize. Many different areas of project developing have been get benefits from the advantages of those optimization techniques, specially when used in structural projects. They are in constant progress and thanks to the emergence of CAD/CAM programs and novel manufacture techniques as 3D printing, today it is possible obtain solutions that we couldn t image before. The topology optimization is one of those techniques which is becoming notorious, it s based in the Finite Element Method. When the domain is defined and the boundary conditions, as fixed points and loads are set, the method looks for the best material distribution inside that domain that tend to solve the minimization problem of certain parameters as compliance, volume or mass for example, it depends on the objective that was set. The object of this present study can be see as a medical problem only, but a solution that evolves engineering knowledge will be presented. The case of study is a craniofacial implant problem, which is very complex as the solution is highly personalized, this is because we should take in count that every human is unique, and in this specific problem it s not common to test a prototype in the patients. That s why the topology optimization is implemented as solution for this problem, it permits to reach the design requirements. Firstly more details of this problem will be show as the methodology adopted for the solution. In that case is used AnsysWorkbench 18.1, a commercial program, where is possible to generate the optimized geometry that correspond to the requirements, after that the geometry received a treatment to make it feasible. Structural analysis was made in ANSYS Mechanical to certify that the geometry responds as a structural body and supports the loads. Finally a file is generated for 3D printing. The procedures adopted and the results will be comment as the problems that was seen during the job and the suggestions for future work.