The poor working conditions of bus drivers is a problem known to most of society, and is present in all Brazilian states. As a resident of the city of Rio de Janeiro, I carried out this monographic research in order to identify the main variables that affect the quality of life at work (QLW) of urban bus drivers in the city. Using theories that deal with the physical and mental consequences to which workers acquire to the detriment of their environment and work activity, such as QLW and Occupational Hygiene, I was able to understand what and how the variables affect workers in this professional activity.