After personal experience as a psychotherapist at the University Hospital João de Barros Barreto in the city of Belém, treating patients with HIV / AIDS, the researcher came across cases where patients had self-incrimination speeches related to their diagnosis. From these cases, it was first developed one dissertation which dealt with the issue of trauma reinstated by the diagnosis of AIDS and its possible redefinition. The PhD project represents a motivation to continue the investigation into the subjectivities rebuilt after positive diagnosis of AIDS. Therefore, this study investigated the relationship between the unconscious sense of guilt and a sense of shame, as proposed in psychoanalytic theory, and psychological distress produced with the positive diagnostic communication for HIV / AIDS. Talking about AIDS stills difficult nowadays. Furthermore, speaking of AIDS-related sexuality is much more complicated. Taboo subjects (sex and death associated with the diagnosis of disease) and the imaginary about the AIDS epidemic, sentenced over its history groups were ordered to pay for the sin that brought AIDS, placing it within our houses. Prejudgement is still very strong to subjects with the disease, which is manifested by feelings of guilt and shame. This work aims, thereby, to contribute to the development of knowledge, linking theory and psychoanalytic practice, taking into account the woman, and its place in culture and society, and thinking forms of subjectivity involved in the AIDS issue. In order to discuss the impact of AIDS, we need to discuss their sexuality. What has proposed with this work was to think of the feelings of shame and guilt as the bond holders and the social pact and how the AIDS diagnosis is an event that endangers not only the subject s life as social life.