This dissertation studies the effects of compartmentalization of tank trucks on the operation of automotive fuels distribution plants. The operation is part of the supply chain of such fuels. This work looks at the current trend of compartment modification and assesses the impact of this modification in that portion of the distribution chain. The present work is intended as a basis for future studies aimed at evaluating the trade-offs that exist in this type of operation in order to allow for cost reductions. The initial part of this dissertation examines current practices in the industry. Next, the work reviews the bibliography containing the main theoretical principles which frame this study. This is followed by a model and a simulation study focusing on how compartmentalization impacts distribution plant operations. The final part presents the results of the simulation study applied to the different scenarios proposed. This work also offers comments on the potential use of the simulation study technique - and, in particular, the model herein - in analyses of alternative scenarios, as well as suggestions of other studies related to this topic.