Título: | COPPER(II) COMPLEXES DERIVED FROM NACYLHYDRAZONIC LIGANDS AS AN ANTITUMOR ALTERNATIVE TO PLATINUM COMPOUNDS: SYNTHESIS, CHARACTERIZATION, STUDIES IN SOLUTION AND PHARMACOLOGICAL POTENTIAL | ||||||||||||
Autor: |
FAGNER DA SILVA MOURA |
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Colaborador(es): |
NICOLAS ADRIAN REY - Orientador |
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Catalogação: | 13/JAN/2025 | Língua(s): | ENGLISH - UNITED STATES |
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Tipo: | TEXT | Subtipo: | THESIS | ||||||||||
Notas: |
[pt] Todos os dados constantes dos documentos são de inteira responsabilidade de seus autores. Os dados utilizados nas descrições dos documentos estão em conformidade com os sistemas da administração da PUC-Rio. [en] All data contained in the documents are the sole responsibility of the authors. The data used in the descriptions of the documents are in conformity with the systems of the administration of PUC-Rio. |
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Referência(s): |
[pt] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=69117&idi=1 [en] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=69117&idi=2 |
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DOI: | https://doi.org/10.17771/PUCRio.acad.69117 | ||||||||||||
Resumo: | |||||||||||||
Cancer can be considered a collection of various diseases that collectively
lead to an imbalance in the tissues from which they originate. The genesis of
tumors is generally associated with mutations that accumulate within cells. The
altered cell acquires an increased capacity of proliferation, undergoing clonal
expansion and transmitting its genes to daughter cells. Disordered proliferation
can form a solid and intricate mass of altered cells within the organ where the
tumor originated.
Current cancer treatments focus on diagnosing the type of cell, its location
and severity, guidance, selecting the best treatment options, and monitoring the
progress. In the latter half of the 1960s, Rosenberg discovered the antitumor
activity of cisplatin, which spurred the search for new metal-based anticancer
agents. Despite this, few inorganic anticancer drugs have shown auspicious due to
toxicity issues.
In this context, N-acylhydrazones and their copper(II) complexes have
been suggested as promising compounds for achieving this objective. Copper(II)
complexes have been presented in the literature as an alternative to platinum-based anticancer compounds, given that copper is an essential trace element with
fewer side effects. In recent decades, many copper(II) coordination compounds
exhibiting antitumor activity have been reported as promising active compounds
against tumor cells, with some advancing to clinical trials, such as Casiopeínas (trademark),
which interact with cells in various ways.
Our research group has experience with copper(II) complexes exhibiting
reported antitumor activity. Additionally, N,O-donor N-acylhydrazone ligands,
both free and coordinated, have demonstrated biological activity as anticancer
agents. This has motivated the design of a new generation of similar ligands to
enhance antitumor activity. This work encompasses the synthesis, acquisition, and
complete characterization of novel N-acylhydrazone ligands, which were
thoroughly characterized, as well as their new copper(II) complexes obtained from
three different starting salts. The study includes the reactivity, spectroscopic,
electrochemical, and antiproliferative properties of a new generation of mono- and
binuclear copper(II) complexes derived from these N-acylhydrazone ligands. Of
the ten synthesized complexes, six showed reactivity towards human serum
albumin (HSA), and three complexes derived from the ligand containing furan as
a substituent had their antiproliferative activity evaluated, exhibiting greater
activity than cisplatin.
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