INMETRO Ordinance No. 291, dated July 7, 2021, establishes a maximum permissible error of 1.0 percent for the final value obtained by the dynamic measurement system of Liquefied Petroleum Gas (LPG), i.e., the mass of LPG. Additionally, the regulation univariately defines maximum errors for associated quantities, such as static pressure, temperature, and density. The objective of this dissertation was to propose the optimization of the acceptance criteria for the calibration of instruments associated with the LPG measurement system, based on the principles established by INMETRO Ordinance No. 291. The motivation for this study was the need for a multivariate evaluation aimed at optimizing the acceptance criteria limits for the calibration of these secondary instruments in the dynamic LPG measurement system. The application of methodologies such as Box-Behnken and Doehlert experimental designs, and Response Surface Analysis, proved effective since the results obtained defined, in a multivariate manner, optimized criteria limits for the calibration of each of the above-mentioned secondary transmitters. Finally, it was concluded that it was possible to exceed the proposed limit values while still maintaining the output variable (LPG mass) within the maximum permissible error of 1.0 percent for the measurement system. As a direct consequence, unnecessary disposal of instruments that would initially not meet the required parameters was avoided, while maintaining the level of reliability required by the regulatory ordinance.