In light of the recent significant growth in technological capabilities andthe observed advancements in the field of computational intelligence, the latterhas demonstrated potential for application in various sectors of society. Inthe context of extreme competitiveness and increasing relevance in the mostfamous sports around the world, basketball presents itself as an interestingsport for the application of decision-support mechanisms capable of enhancingthe efficacy and consistency of team victories in championships. In this context,this study proposes the development of decision-support systems, such asneural networks and k-Nearest Neighbors (kNNs). The goal is to evaluate, foreach substitution during a match, which group of players in the field, knownas lineup, presents the most probability to be superior to their opponent. Forthis, models were trained to predict, during a sequence of possessions, theteam that would have advantage and the magnitude of this advantage. Thedatabase was obtained from Novo Basquete Brasil (NBB) matches, involvingplayers statistics, match details and different contexts.. The model achieved anaccuracy of 76,99 percent in projections of superiority between the playing lineups,demonstrating the potential of using computational intelligence methods indecision-making applied to professional sports. Finally, the study highlightsthe importance of using such tools in conjunction with human experience,encouraging future research for the development of even more sophisticatedand effective models for decision-making in the sports field.