The present research, entitled Mysticism as the presence of God in the work of Fulton Sheen, seeks to reflect on the life and work of the American bishop, philosopher and theologian, Fulton Sheen (1895-1979), in the light of his reflection on mysticism Christian. Starting from a philosophical critique of modern religion and the current eclipse of God, the author questions the absence of God and proposes a reinterpretation of the Christ event, in the mystery of his incarnation-death-resurrection, to substantiate the definitive presence of God in the world and in history. The presence of Christ, according to Fulton Sheen, has its extension in the Mystical Body of Christ, the Church. Thus, the historical presence of the Being of Christ, through the Church, makes possible a true mystical experience, not of ecstasy, but of a loving, humanizing and deifying encounter.