The dissertation understands the colonization of the Americas as a fundamental milestone of modern international politics and defends the need for the discipline of International Relations to engage with indigenous peoples, especially by understanding the global role of their political struggles. In this context, it investigates the global and colonial dimensions of the threats to indigenous territories, especially the domination strategies operated in the Xingu Indigenous Territory, threatened by the economic frontiers of agribusiness and illegal logging. With the analysis of bandeirantismo as the guiding thread of the entire dissertation, the work is structured in three movements. The he first movement presents the historical panorama of the Xingu Indigenous Territory, through the intersection between critical historical anthropology, ethnoarchaeology and the postcolonial perspective, in order to understand the threats and resistances to bandeirantismo and the contemporary consequences of the colonial situation in the first demarcated Indigenous Land in Brazil. The second movement analyses, on the one hand, the centrality of bandeirantismo in Brazilian colonization and, on the other, its role in the formation of global capitalism and in the subjectivation of an imperial way of life, based on Eurocentrism and racism. The third movement analyzes the colonial strategies of domination towards indigenous peoples and their territories in two different historical moments, identifying the continuity of the "war of conquest" after independence. Finally, the fourth movement analyzes the territorial tensions and strategies of domination that affect the Xingu Indigenous Territory in contemporary times, understanding how the discourses and practices of international politics operate locally through the articulation between the grammars of political economy and colonial hierarchies. In this way, the dissertation argues that the threats to indigenous territories are consequences of the dynamics of global power patterns, forged from the colonization of the Americas and the consolidation of capitalism. The invasions of indigenous territories during the 17th and 18th centuries, orchestrated by the colonial project and carried out by the bandeirantes, were cricial to the process of structuring global power patterns, whose violent dynamics of the imperial way of life constitute the basis of modern international politics. Thus, engaging with indigenous peoples struggle for their territories represents an engagement with the central actors and disputes of international politics.