The present work intends to analyze how disinformation is monetized on the virtual environment and comprehend the concrete and structural regulatory aspects to reduce the damaging effects of said practice. Thus, the concept of disinformation and programmatic advertising will be shown, as well as the link between them. By virtue of many benefits gerated by this kind of advertising and the risks to the freedom of speech that can come from regulation focussed on contente, solutions based on the the architecture of the plataform and personal data privice protection are presented. As a proposal, a multi-stakeholder regulation is presented with te amplitude of mechanisms and with the mix of the most accurate and vague concepts looking for legal security without neglecting the elasticity there is required in view of the dynamics that involves new thecnologies. Finally, concrete measures designed for (ii) transparency andu ser empowerment are presented; (ii) transparency and control for the advertiser; (iii) accountability and personal data.