An analytical study about the synthesis of metal complexes of amino acids in solid state was performed in this work. Binary and ternary complexes of the amino acids aspartic acid, guanidinoacetic acid, serine and glycine with the metal ions copper (II), nickel (II) and cobalt (II) were synthesized. Although several studies of these complexes in solution have been done before, many questions about the interactions between the ligands and some transition metals ions, still remained unanswered. The necessity of controlling the synthesis conditions directed this study toward the development of an specific methodology to be applied to this important class of compounds: the amino acids. With the aim of adding knowledge to the research about the synthesis of compounds in the solid state, a methodology was developed that allows the systematic synthesis of metal complexes with amino acids. The association of graphs of the several equilibria involved in the synthesis lead to the elaboration of a graphical methodology to control the various parameters that interfere in both yield and quality of the final product, reducing unwilling effects such as hydroxide formation and the presence of excess of water. For the characterization of the compounds, several techniques were used: infrared spectroscopy, thermogravimetric analysis, atomic absorption spectrometry and qualitative analysis. With a more accurate control of the work conditions, crystals were obtained. These compounds were characterized by X-ray diffraction and infrared spectroscopy. The results of this work showed that a rigorous control of the composition of the final products is of crucial importance, with special attention to the compounds that are able to absorb water, since this is a variable that affects the infrared spectrum and masks the results of the characterization techniques. The success of the application of the graphical methodology in the synthesis of complexes produced various compounds in the form of powder or crystal. In some cases new ligands were obtained during the crystallization process, suggesting that interactions between the ligands occurred.