The glucagon-like peptide 1 (GLP-1) receptor agonist is used for the treatment of type 2 diabetes (DM2) as it improves glycemic control, reduces appetite and body weight. It is also related to altered brain responses to food stimuli, but its effects on intrinsic brain connectivity are unknown. With the goal of better understanding GLP-1 s role in the intrinsic brain connectivity of DM2 patients, functional resonance imaging (fMRI) data of resting-state networks relevant for eating behavior was analyzed in two studies. In both, all images were acquired after an overnight fast (8-12 hours). Study 1 aimed to investigate the acute effect of GLP1 blockade on functional connectivity. On two separate days, fMRI data was acquired from 20 DM2 patients and 20 healthy controls, first under saline infusion and thereafter under GLP-1 antagonist infusion. Study 2 aimed to investigate, in DM2 patients, if there were any between treatment differences in intrinsic connectivity when comparing GLP-1 receptor agonist liraglutide with insulin glargine. The same DM2 participants in study 1 were thus treated in random order for 12 weeks with liraglutide and insulin glargine, fMRI data was collected at the start of treatment, after 10 days and after 12 weeks. Study 1 results showed that, during saline infusion, DM2 patients had greater connectivity compared to controls in the left insula and operculum, which related to greater GLP-1 mediated weightloss after 10 days and 12 weeks. Also, connectivity was greater in DM2 patients versus controls in the frontal pole, frontal medial cortex, anterior cingulate and paracingulate giry, which related to less GLP-1 mediated weight-loss after 10 days (all P(FWE) less than 0.05). There was no effect on connectivity for GLP-1 antagonist, and no long-term differences between treatments (all P(FWE) less than 0.05). In conclusion, baseline resting-state connectivity was shown to be related to GLP-1 mediated weightchange, with greater frontal connectivity relating to less weight loss during GLP-1 treatment, while higher left insula connectivity correlated to greater weight loss during GLP-1 treatment, indicating a relationship between baseline intrinsic connectivity in these regions and weight loss during GLP-1 treatment.