Nowcasting in economics is the prediction of the present, the recent past or even the prediction of the very near future of a certain indicator. Generally, a nowcast model is useful when the value of a target variable is released with a significant delay with respect to its reference period and/or when its value gets notably revised over time and stabilizes only after a while. In this thesis, we develop and analyze several Nowcasting methods using high-dimensional (big) data in different contexts: from the forecasting of economic series to the nowcast of COVID-19. In one of our studies, we compare the performance of different Machine Learning algorithms with more naive models in predicting many economic variables in real-time and we show that, most of the time, Machine Learning beats benchmark models. Then, in the rest of our exercises, we combine several nowcasting techniques with a big dataset (including high-frequency variables, such as Google Trends) in order to track the pandemic in Brazil, showing that we were able to nowcast the true numbers of deaths and cases way before they got available to everyone.