Over the last years, Research Operations development has become fundamental for Aviation Industry. In Brazil, the agency responsible for Civil Aviation inspection is the National Agency of Civil Aviation (ANAC). This work aims the development of an optimal personnel location-allocation model and application in a case study at ANAC in Safety Oversight context. One Literature Review has been done for gaps identification and to find the most recent solution techniques for facility location problems. The research objective has been achieved, and the proposed case study has validated the model. The model located 31 percent of ANAC personnel in Brazilian Southeast Region, 25 percent in Northeast Region, 17 percent in North Region, 17 percent in South Region and 10 percent in Central-West Region; decreasing in 66 percent the total quantity of allocated inspectors. A capacities matrix has been constructed with model results; decision-makers can analyze the optimal distribution of personnel capacities in each facility. Finally, a sensitivity analysis has been done to test the model flexibility, which prove the model is efficient for real problems application.