The objective of this thesis is to reflect on the narrative possibilities and challenges that digital culture brings to the dialogue between museums and their audiences and on the role of Design in this process. We assume that the digital culture that permeates contemporary society has intrinsic characteristics that facilitate the understanding of the museum as an important institution for the cultural development of the population. New possibilities, through the various technologies available, intensify and democratize its interaction with their public. In the study, concepts by Lévy (1999, 2001), Bauman (2001, 2013), Manovich (2001, 2008) and Eli Pariser (2012) about contemporaneity are articulated with the thoughts of authors in the areas of Museum and Design. Design is understood as an activity that, in addition to materializing tangible objects, also focus on the possibilities of interaction between people and products. Likewise, museums should not be understood as spaces concerned only with the organization, preservation and exhibition of artifacts, but perceived as centers that disseminate information and encourage the construction of critical thinking, which maintain relationships with the social context in which they are inserted. A mapping of trends and challenges concerning the adoption of digital technologies in museums is produced. In order to relate the theoretical foundation with practical experience, a field research is carried out, using different methodological resources. The perspectives of professionals working in museums were collected through interviews; and the elaboration and evaluation by the public of an experiment in virtual reality, through a questionnaire. The experiment focused on the digital reconstruction and 3D visualization of a mummy from the Egyptian collection of the National Museum of Rio de Janeiro, destroyed in the fire that occurred at the institution s headquarters in 2018. The results of the evaluation carried out with 153 users, through a questionnaire, indicate that new narrative forms contribute to expand the dialogue between museums and their audiences; to enhance the enjoyment of their collections; and also to help in the democratization of knowledge. The experiment showed that meaningful experiences mediated by technologies represent complex challenges that require collaborative work among institutions and interdisciplinary teams. The results also pointed out that for digital technologies to be fully adopted, it is necessary to combine innovative creation and communication strategies with continuous investments in the technological training of teams, equipment and management. In this process, the role of Design becomes fundamental in creating favorable conditions for the relationship between the public and the collection to be strengthened. The interviews also showed that Design s potential is underused in museums internal teams, indicating that the Design-Museum interaction still has a lot to be explored. The Covid-19 pandemic intensified the digital communication of most museums with the public, accelerating the process of adopting digital technologies in these institutions.