This thesis presents the hypothesis that psychoanalytic process implicates in creative perdition. By this expression it intends to emphasize the loss experience as much as the awakening of desire. Both incite a sensation of disorder, associated to a traumatic experience. Nevertheless, they are necessary to promote the invention of an original way of living. The thesis starts with the study of the death drive, formulated by Freud and elaborated anew by the psychoanalysts Jacques Lacan and MD Magno, in order to investigate the creation phenomenon, as related both to culture and psychoanalytic clinic. By associating death drive to the tragic character of existence, this thesis establishes a dialogue between psychoanalysis and Friedrich Nietzsche s thought.