Virtual Reality has been disseminated in several areas of knowledge, including the field of Psychology, for example being used as a therapeutic method and in scientific research. One of these uses as an experimental tool is as a Mood Induction Procedure, in which the individual experiences a virtual environment mediated through electronic equipment. This dissertation presents two articles related to this theme. The first is a systematic review carried out to explore ways in which Virtual Reality can be used as a mood induction procedure. In this review we found evidence for the efficacy of the method, in addition to identifying the Headmounted Display equipment as the most used, college students as the most common sample and electrodermal activity as the most frequently used physiological measure. The second article presents an empirical study investigating Virtual Reality as a mood inductor and how it can be used to promote emotional reactivity and improve interoception. The analyses indicated significant increases for electrodermal activity in an emotional condition elicited by Virtual Reality. Moderate to large effect sizes were observed for negative emotional reactivity and for interoception, which could be significant with a larger sample. Heart rate results did not show significant differences. The presented results of the electrodermal activity indicate successful mood induction. This study is relevant for presenting new procedures and technologies to assist in research in psychology, with Virtual Reality being a potential experimental tool. The clinical character of the study is reinforced by the promising results of the pilot study in relation to interoception, suggesting that Virtual Reality may be employed in clinical treatments, helping subjects to identify and discern their emotions and sensations in emotional situations, which would allow the development of more adaptive responses.