Spatial truss structures are geometrical arrangements of bars widely used in building roofs. Several factors favor their use, such as the ability to overcome large spans and the capability of assuming a variety of configurations. The search for optimal geometry is an important goal in the design of structures, where the main interest is to minimize the cost of the structure. The objective of this work is to present a computational system capable of minimizing the weight of truss structures whose geometry is defined by Bézier curves. Therefore, the control points of the Bézier curves are used as design variables. The cross-sectional areas of the bars and the truss height are also considered as design variables and constraints on the yield stress and Euler critical stress are imposed on the optimization problem. The structure is analyzed using truss elements considering the physical and geometric linear behavior. The optimization algorithms used in this work require the gradient of the objective function and constraints with respect to the design variables. The computational system developed in this work was written in MATLAB and has an integration with SAP2000 through the OAPI (Open Application Programming Interface). The obtained numerical results demonstrate the efficiency and applicability of the developed system.