Burnout is a psychological syndrome resulting from the chronic stress of the work environment. It is characterized by three dimensions: Emotional Exhaustion, Depersonalization and Low Personal Accomplishment. The objective of the present study was to investigate the role of sociodemographic variables (gender, age and level of education), contextual factors and personality traits in the outcome of burnout. In total, 343 Brazilian professionals (75.80 percent women) responded to an online battery of surveys. The interviewees were active in the areas of health, education, administrative services, security, banking and customer service (e.g. telemarketing, call centers). The results obtained did not present a statistically significant relationship between sociodemographic variables and burnout. Neuroticism and Openness to experience were the personality traits that presented significant relation with all dimensions of Burnout and Socialization, with the Depersonalization dimension. For all Burnout factors, Neuroticism was the most important predictor (Beta = 0,60 to Emotional Exhaustion, Beta = 0,48 to Depersonalization and Beta = 0,62 to Low Personal Accomplishment). Personal resources, especially personality traits, have an important relation with burnout, especially the trait of Neuroticism.