The presente research analyze the configuration of the Fifth Dimension educational program, created by Michael Cole, a prominent researcher in contemporary sociohistorical-cultural psycology studies, promoting mediated learning by the use of ICT for the cognitive development of children with intelectual disabilities. Created in the United States of America, the Fifth Dimension Program joins universities and communities in order to attend socially marginalized children with low school performance. An important feature of this program is its adaptability to the specific requirements of each community of practice. In this way, the program can be adapted to different social settings, languages and cultures. The present study analyze the general configuration of the program and of two adaptations: Metacognitive Dimension Program implemented by the Sarah Network of Neurorehabilitation Hospitals and the Cinquena Dimensión programa of the Shere Rom House in Spain. The research procedures was mainly analysis of the reference documents of these programs, in triangulation with: interview with the coordinator of the Sarah Network program; interview given by Michael Cole to Professor\Zena Eisenberg; and description of technical visit made by the researcher to the Rehabilitation Hospital of the Sarah Network in Brasilia. We identified that the Fifth Dimension presents a defined pedagogical structure and outlines the methodology of implementation, composed of three key elements: technologies for cognitive development; mediation and centrality of centrality of cultural context. Consistent with the sociohistorical-cultural perspective, the program is structurally adaptable to the local requirements.