The development of petroleum fields affects substantially the geological environment around the reservoir. The geomechanical effects arising from hydrocarbon exploration may present harmful effects on the integrity of the system components, particularly the wells. The aim of this work was to analyze the reservoir development effects over the well integrity, employing fluid-mechanical and multi-scale simulations. For the global analyzes, it was implemented and validated a fluid-mechanic partial coupling configuration, using the reservoir simulation software IMEX and the stress analysis software ABAQUS, based on the coupling methodology developed by the Group of Technology and Petroleum Engineering of PUC-Rio. The theoretical connection between the models of reservoir and wells was established by a multi-scale workflow, which was developed to guide the well integrity analysis due to production effects. In order to optimize the numerical connection between distinct scale models, it was developed a local analysis manager, called APOLLO module, which can include the steps of drilling and completion, as well as the geomechanical effects from the global simulation, in the local simulations. Coupled multi-scale analyzes were performed in two hypothetical wells, present in a reservoir model based on the geometry of the Namorado Field. Through the tools developed in this Thesis, it was possible to perform a detailed and accurate prediction of the mechanism that leads the evaluated wells to the collapse. It was found that the character of the observed limit states was essentially three-dimensional, as well as dependent of the coupling approach employed on the global simulation.