ETDs @PUC-Rio
| Título: | MN(II) AND CO(II) COMPLEXES WITH THIOSEMICARBAZONES AND FLUORQUINOLONES: SYNTHESIS, SPECTROSCOPIC AND ELECTROCHEMICAL STUDIES AND BIOLOGICAL ACTIVITY | ||||||||||||||||||||||||||||||||||||||||
| Autor: |
RENATA SOBRAL SILVA |
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| Colaborador(es): |
LETICIA REGINA DE SOUZA TEIXEIRA - Orientador |
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| Catalogação: | 15/SET/2009 | Língua(s): | PORTUGUESE - BRAZIL |
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| Tipo: | TEXT | Subtipo: | THESIS | ||||||||||||||||||||||||||||||||||||||
| Notas: |
[pt] Todos os dados constantes dos documentos são de inteira responsabilidade de seus autores. Os dados utilizados nas descrições dos documentos estão em conformidade com os sistemas da administração da PUC-Rio. [en] All data contained in the documents are the sole responsibility of the authors. The data used in the descriptions of the documents are in conformity with the systems of the administration of PUC-Rio. |
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| Referência(s): |
[pt] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=14131&idi=1 [en] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=14131&idi=2 |
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| DOI: | https://doi.org/10.17771/PUCRio.acad.14131 | ||||||||||||||||||||||||||||||||||||||||
| Resumo: | |||||||||||||||||||||||||||||||||||||||||
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Thiosemicarbazones and fluorquinolones are a class of compounds
presenting a wide range of pharmacological activities. In the present work a study
of thiosemicarbazones and their Mn(II) and Co(II) complexes with potential anti
parasite and antitumoral activities was carried out along with an investigation of
Mn(II) and Co(II) complexes of norfloxacin and sparfloxacin with antimicrobial
activity. N(4)-methyl thiosemicarbazones derived from 4-nitrobenzaldehyde
(H4NO2Fo4M), 4-nitroacetophenone (H4NO2Ac4M) and 4-nitrobenzophenone
(H4NO2Bz4M) and their Mn(II) and Co(II) complexes, [Mn(H4NO2Fo4M)2Cl2],
[Mn(H4NO2Ac4M)2Cl2], [Mn(H4NO2Bz4M)2Cl2], [Co(H4NO2Fo4M)2Cl2],
[Co(H4NO2Ac4M)2Cl2], [Co(H4NO2Bz4M)2Cl2], were obtained and
characterized. The crystal structure of H4NO2Fo4M has been determined.
Electrochemical studies have shown that the Ar-NO2, one of the proposed
intermediates in the mechanism of action of nitro-containing anti-trypanosomal
drugs, is formed at approximately -1.00 V in the free thiosemicarbazones as well
as in their corresponding Mn(II) complexes, suggesting their potential to act as
antitrypanosomal drugs. The natural fluorescence of H4NO2Fo4M, H4NO2Ac4M,
H4NO2Bz4M and Mn(II) and Co(II) complexes provides a way to identify and to
monitor their concentration in biological systems. The toxicity of the
thiosemicarbazones and their Mn(II) complexes against Artemia salina was
assayed as a prescreening for antitumoral action. The low values of CL50;48h
obtained for the studied compounds in this assay indicate that they could present
antineoplastic properties. One of the major problems in the clinical treatment of
infection by bacteria is the appearance of resistance and therefore the search for
new drugs is extremely important. In many cases resistance mechanisms recognize the ligand but cannot recognize its metal complex. In the present work
Mn(II) and Co(II) complexes of norfloxacin and sparfloxacin,
[MnCl2(NOR)(H2O)2], [CoCl2(NOR)(H2O)2], [MnCl2(ESPAR)(H2O)2] and
[CoCl2(ESPAR)(H2O)2] were obtained and their antibacterial activity against
Staphylococcus aureus has been tested. We believe that this work contributes for a
better knowledge of the chemistry of thiosemicarbazones and fluorquinolones and
their pharmacological properties.
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