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Título: NEW DINUCLEAR ZN(II), CU(II) AND NI(II) COMPLEXES OF THE LIT LIGAND: POTENTIAL ANTINEOPLASTIC AGENTS
Autor: CAMILA MARIA INACIO DE ASSIS
Colaborador(es): NICOLAS ADRIAN REY - Orientador
Catalogação: 21/DEZ/2021 Língua(s): PORTUGUESE - BRAZIL
Tipo: TEXT Subtipo: THESIS
Notas: [pt] Todos os dados constantes dos documentos são de inteira responsabilidade de seus autores. Os dados utilizados nas descrições dos documentos estão em conformidade com os sistemas da administração da PUC-Rio.
[en] All data contained in the documents are the sole responsibility of the authors. The data used in the descriptions of the documents are in conformity with the systems of the administration of PUC-Rio.
Referência(s): [pt] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=56698&idi=1
[en] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=56698&idi=2
DOI: https://doi.org/10.17771/PUCRio.acad.56698
Resumo:
Cancer is a name given to a set of more than 100 diseases and among the possibilities of treatment is chemotherapy. After the discovery of the antitumor properties of the coordination complex commonly called cisplatin, it is one of the compounds most used in malignancies. The study of metal complexes had a big boost and some promising copper(II) compounds have been developed. Furthermore, the Schiff bases derived from aromatic aldehydes and amines present a wide range of applications in many areas of research, some of which are pharmacologically used in antihypertensive, hypnotic, and antineoplastic therapy. In this context, in the present study, we synthesized and characterized a binucleating imine ligand, derivative of taurine, already known in the literature: (LIT). New dinuclear Zn(II), Cu(II) and Ni(II) complexes of this ligand were synthesized, and were characterized by the following techniques: vibrational and electronic spectroscopies, CHNS elemental analysis, thermogravimetric analysis, electron paramagnetic resonance (EPR) and computational molecular modeling. The new compounds obtained in this work are: composite (1), composite (2) composite (3), where LIT represents a LIT partially hydrolyzed form. Complexes 1 and 2 are the first dinuclear compounds of the LIT ligand described. In these, metal centers are tetracoordinated, with the presence of an exogenous acetate bridge, which shows a bidentate coordination mode for compound 1 and a monodentate coordination pattern for 2. This difference occurs probably due to different geometrical arrangements around the metal centers: while zinc has a tetrahedral coordination geometry, copper shows one of the square planar type. On the other hand, compound 3 a dinuclear complex, which is composed of a highly symmetric dimer involving, as mentioned above, a partially hydrolyzed form of LIT. The hexacoordinated metal centers are connected by two endogenous phenolic bridges. Both 2 and 3 are EPR silent. An acute toxicity test on Artemia salina shrimp was also carried out for the hydro-soluble species LIT and 1. This assay shows good correlation with cytotoxic activity for some human solid tumors.
Descrição: Arquivo:   
COVER, DEDICATION, THANKS, RESUMO, ABSTRACT, SUMARY, LISTS, EPIGRAPH PDF    
CHAPTER 1 PDF    
CHAPTER 2 PDF    
CHAPTER 3 PDF    
CHAPTER 4 PDF    
CHAPTER 5 PDF    
REFERENCES PDF