Título: | NEW DINUCLEAR ZN(II), CU(II) AND NI(II) COMPLEXES OF THE LIT LIGAND: POTENTIAL ANTINEOPLASTIC AGENTS | ||||||||||||||||||||||||||||||||||||
Autor: |
CAMILA MARIA INACIO DE ASSIS |
||||||||||||||||||||||||||||||||||||
Colaborador(es): |
NICOLAS ADRIAN REY - Orientador |
||||||||||||||||||||||||||||||||||||
Catalogação: | 21/DEZ/2021 | Língua(s): | PORTUGUESE - BRAZIL |
||||||||||||||||||||||||||||||||||
Tipo: | TEXT | Subtipo: | THESIS | ||||||||||||||||||||||||||||||||||
Notas: |
[pt] Todos os dados constantes dos documentos são de inteira responsabilidade de seus autores. Os dados utilizados nas descrições dos documentos estão em conformidade com os sistemas da administração da PUC-Rio. [en] All data contained in the documents are the sole responsibility of the authors. The data used in the descriptions of the documents are in conformity with the systems of the administration of PUC-Rio. |
||||||||||||||||||||||||||||||||||||
Referência(s): |
[pt] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=56698&idi=1 [en] https://www.maxwell.vrac.puc-rio.br/projetosEspeciais/ETDs/consultas/conteudo.php?strSecao=resultado&nrSeq=56698&idi=2 |
||||||||||||||||||||||||||||||||||||
DOI: | https://doi.org/10.17771/PUCRio.acad.56698 | ||||||||||||||||||||||||||||||||||||
Resumo: | |||||||||||||||||||||||||||||||||||||
Cancer is a name given to a set of more than 100 diseases and among the
possibilities of treatment is chemotherapy. After the discovery of the antitumor
properties of the coordination complex commonly called cisplatin, it is one of
the compounds most used in malignancies. The study of metal complexes had a
big boost and some promising copper(II) compounds have been developed.
Furthermore, the Schiff bases derived from aromatic aldehydes and amines
present a wide range of applications in many areas of research, some of which are
pharmacologically used in antihypertensive, hypnotic, and antineoplastic therapy.
In this context, in the present study, we synthesized and characterized a
binucleating imine ligand, derivative of taurine, already known in the literature:
(LIT). New dinuclear Zn(II), Cu(II) and Ni(II)
complexes of this ligand were synthesized, and were characterized by the
following techniques: vibrational and electronic spectroscopies, CHNS elemental
analysis, thermogravimetric analysis, electron paramagnetic resonance (EPR) and
computational molecular modeling. The new compounds obtained in this work
are: composite (1), composite (2)
composite (3), where LIT represents a LIT partially
hydrolyzed form. Complexes 1 and 2 are the first dinuclear compounds of the LIT
ligand described. In these, metal centers are tetracoordinated, with the presence of
an exogenous acetate bridge, which shows a bidentate coordination mode for
compound 1 and a monodentate coordination pattern for 2. This difference occurs
probably due to different geometrical arrangements around the metal centers:
while zinc has a tetrahedral coordination geometry, copper shows one of the
square planar type. On the other hand, compound 3 a dinuclear complex, which is
composed of a highly symmetric dimer involving, as mentioned above, a partially
hydrolyzed form of LIT. The hexacoordinated metal centers are connected by two
endogenous phenolic bridges. Both 2 and 3 are EPR silent. An acute toxicity test
on Artemia salina shrimp was also carried out for the hydro-soluble species LIT
and 1. This assay shows good correlation with cytotoxic activity for some human
solid tumors.
|
|||||||||||||||||||||||||||||||||||||
|