Cities and Industries are interdependent and determinant among themselves. However, since the first cycle of industrialization in England at the end of the 19th Century, the conflicting coexistence between manufacturing and inhabited areas seems irreconcilable. Modernist planning proposed Industrial Districts designed under a Keynesian perspective. In contemporary times, industrial zones has followed a globalizing logic. Transnational corporations determine on a planetary scale where to locate their production platforms, in favor of profits maximization. This movement is ruled – but also facilitated – by the State in a balance between national interest and a business-friendly ambient (Harvey, 1989). Industries and other sectors of the cities need to be close. The question is: how close? Is there a desired distance that guarantees to the City and its inhabitants the highest positive externalities of industrialization, reducing, however, negative impacts and discomforts? Does environmental technology have a real capacity to positively interfere? Which elements should base environmental and neighborhood impact assessments so that: (i) emergent conflicts can be solved; or (ii) due and fair measures can be establish to overcome or compensate for the negative impacts; and (iii) early precise assessments precede new ventures? This research aims at proposing a decision-aiding method for the management of neighborhood impacts (not regulated by laws or standards), identifying aspects to facilitate coexistence between industries and neighbors.