The present study aims to analyze the impact of infant leukemia on children s subjectivity. Thus, it attempts to describe the particular aspects of this experience that includes an aggressive treatment, a series of restrictions, invasive and painful medical procedures, and the risk of death. The research aims to investigate how these aspects relate to the child still in the development period, considering these experiences as presenting a traumatic potential for the challenge imposed by the disease and hospitalization. This work is guided by the psychoanalytic theory and introduces the concept of trauma by Sigmund Freud, Donald Winnicott and Sándor Ferenczi. To listen about the experiences of children in treatment for leukemia, semi open interviews were conducted in Hemorio (State Institute of Hematology Arthur de Siqueira Cavalcanti). A qualitative analysis of the narratives highlights the specific aspects of trauma, such as the excess, the helplessness, the invasions, the denial and the threat of death. Thus, from the impact remains the need to elaborate: through narrating and playing.